‘anti-hunger’ molecule forms after intense exercise, scientists find

Why are we so hungry after some workouts, but don’t want to eat after others? In a new study published in the journal Nature, an international team of scientists led by Stanford University suggests that part of the answer lies in the actions of a single molecule produced after exercise that can “suppress” hunger. This molecule was found to be much more abundant after high-intensity workouts than easy workouts, suggesting that high-intensity exercise may be the key to controlling the amount of food consumed afterward. In addition, this molecule has shown how exercise leads to weight loss and may be key to kick-starting the process in people with metabolic disease (a medical condition that affects metabolism in the cell, especially energy production). † Exercise is good for body weight and blood sugar levels. “explained Prof. Jonathan Long, who led the study. † We wanted to look at this concept in more detail, see if we could decompose body movement in terms of molecules† †

From a certain intensity of physical exertion, the molecule in question is a modified amino acid called Lac-Phe. This is synthesized from lactate, a byproduct of intense exercise that is responsible for the burning sensation in the muscles, and phenylalanine (an amino acid that is one of the building blocks of proteins. And not just in humans, because the scientific team also found that this molecule appears after physical exertion in mice and racehorses. Regular exercise has been proven to help weight loss, regulate appetite and improve metabolic profile, especially for overweight and obese people. adds co-corresponding author Dr. Yong Xu of Baylor College of Medicine. †If we could understand the mechanism by which exercise produces these benefits, we would be one step closer to helping many people improve their health.† To arrive at this finding, the researchers conducted extensive blood plasma analyzes of mice after strenuous running on the treadmill.

Less appetite, less food, easier weight loss?

By comparing the data recorded before and after the exercise session, the scientists identified several molecules whose presence increased and one of them stood out: Lac-Phe. The research team then realized that this peak also occurs in horses and humans, and that it is really caused by exercise and not by other factors, such as stress. But the chemical and biological role of this molecule remained unknown: how does it work? Lactate, the molecule that gives a burning sensation at the end of intense sessions, increases in our body and this peak causes the union of lactate and phenylalanine. The study showed that the union of lactate and phenylalanine is catalyzed by a protein called CNDP2, which has high activity in immune and other cells, including skin cells. † Specifically, this means that when we exercise, many types of immune cells detect lactate and then CNDP2 helps create Lac-Phe. adds Professor Jonathan Long.

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The researchers then hypothesized that Lac-Phe might have something to do with energy balance after exercise, since the cells in the blood and elsewhere that create it are largely involved in energy supply and body mass. To find out whether the molecule might indeed affect appetite, they introduced diet-induced obesity to a high dose of Lac-Phe, which reduced their food intake compared to control mice over a 12-hour period. The molecule was given to mice for 10 days and reduced cumulative food intake and body weight (through loss of body fat) and improved glucose tolerance. † We found that their food intake was suppressed by about 30%. Professor Long notes. † This resulted in lower body weight, less fat and improved glucose tolerance, indicating a reversal of diabetes. We thought: All this evidence really suggests that lac-phe goes to the brain to suppress the urge to eat† †

However, the researchers would like to point out that it is far too early to consider developing a “diet pill” available in pharmacies. This finding, while promising, is just the start of a series of studies that delve deeper into the mechanism of how Lac-Phe inhibits the hunger signal. ‘, they indicate. And yet such a treatment developed, which reproduces the effects of sport on the feeling of hunger, would only be intended for people with a real metabolic disease such as obesity. Good news, however, it is possible to take advantage of the benefits of this molecule in a natural way: by exercising as intensively as possible on a regular basis. Data from a cohort of 8 men performing different types of exercise showed that sprint exercise caused the most dramatic increase in Lac-Phe, followed by resistance training (exercise that causes contraction of the muscles against external resistance, increasing strength and muscle mass) and than endurance training such as cycling.